School of Medicine

Wayne State University School of Medicine

Faculty

 

Faculty members who teach in the graduate program include M.D. and Ph.D. scientists with extensive experience in clinical and basic neuroscience research and in pre- and post-doctoral education. The TNP training faculty members include the following:

 
Deane Aikins, Ph.D. Psychiatry and Behavioral 
Neurosciences; Merrill Palmer Skillman Institute
Cynthia Arfken, Ph.D. Psychiatry & Behavioral Neurosciences
Eishi Asano, M.D., Ph.D. Pediatrics; Neurology
Joyce Benjamins, Ph.D. Neurology, Biochemistry, Immunology and Microbiology  
Bruce Berkowitz, Ph.D. Anatomy & Cell Biology; Ophthalmology
George Borszcz, Ph.D. Psychology
Scott Bowen, Ph.D. Psychology
Susanne Brummelte, Ph.D. Psychology
Paul R. Burghardt, Ph.D Nutrition & Food Science
Leon Carlock, Ph.D. Center for Molecular Medicine and Genetics;
Anatomy & Cell Biology
Alana C. Conti, Ph.D. Neurological Surgery; Pediatric Neurosurgery
Jessica S. Damoiseaux, Ph.D. Psychology; Institute of Gerontology
Donald J. DeGracia, Ph.D Physiology
Vaibhav A. Diwadkar, Ph.D. Psychiatry & Behavioral Neurosciences; Psychology
Alan Dombkowski, Ph.D. Pediatrics
Paula Dore-Duffy, Ph.D. Neurology
Nora Fritz, Ph.D. Pharmacy & Health Science (Physical Therapy); Neurology
Alexander Gow, Ph.D. Center for Molecular Medicine and Genetics; Pediatrics; Neurology
James Granneman, Ph.D. Pathology
Mark Greenwald, Ph.D. Psychiatry & Behavioral Neurosciences; Pharmacy Practice 
E. Mark Haacke, Ph.D. Biomedical Engineering; Radiology
John Hannigan, Ph.D. Obstetrics and Gynecology; Psychology
Jiani Hu, Ph.D. Radiology
Joseph L. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Sandra W. Jacobson, Ph.D. Psychiatry & Behavioral Neurosciences
Arash Javanbakht, M.D. Psychiatry and Behavioral Neurosciences
Csaba Juhasz, M.D., Ph.D. Pediatrics; Neurology
Zhifeng Kou, Ph.D. Biomedical Engineering & Radiology
Donald M. Kuhn, Ph.D. Psychiatry & Behavioral Neurosciences
David Ledgerwood, Ph.D. Psychiatry & Behavioral Neurosciences
Leslie Lundahl, Ph.D. Psychiatry & Behavioral Neurosciences
William Lyman, M.D. Pediatrics; Psychiatry & Behavioral Neurosciences
Otto Muzik, Ph.D. Pediatrics; Radiology; Neurology
Noa Ofen, Ph.D. Institute of Gerontology; Psychology
Shane Perrine, Ph.D. Psychiatry & Behavioral Neurosciences
Christine A. Rabinak, Ph.D. Pharmacy Practice
Naftali Raz, Ph.D. Institute of Gerontology; Psychology
David Rosenberg, M.D. Psychiatry & Behavioral Neurosciences
John SantaLucia, Ph.D. Chemistry
Navid Seraji-Bozorgzad, M.D Neurology
Jeffrey A. Stanley, Ph.D. Psychiatry & Behavioral Neurosciences
Manuel Tancer, M.D. Psychiatry & Behavioral Neurosciences; Pharmacology
John Woodard, Ph.D. Psychology

 

   


 

 

Deane Aikins, Ph.D.
Associate Professor

Psychiatry & Behavioral Neurosciences; Merrill Palmer Skillman Institute

Research Interest

 

Dr. Aikins is a neuroscience and clinical researcher interested in novel treatments of combat stress disorders, investigating both those who are resilient and those diagnosed with Posttraumatic Stress Disorder (PTSD), both in Veterans and military families. He is particularly interested in determining dementia risks in aging Veterans. His research focuses on neuroplasticity as a model for conceptualizing traumatic stress responses, risk and resilience models of PTSD and potential approaches for PTSD treatment.

Disease/Disorder

 

Posttraumatic Stress Disorder, Psychophysiological markers of deployment stress risk and resilience, Deployment stress and emotion regulation in Active Duty military families

Species

 

Human

Methods

 

Psychophysiological markers of ANS activation, fMRI/MRI, diagnostic interviews.

 

Key Collaborators

 

Dr. Julie Wargo Aikins

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

MPSI Profile View

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Cynthia Arfken, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Interested in the fields of substance abuse health services and emerging trends with part of my efforts reserved as epidemiologist and biostatistician for the division. My expertise includes biostatistics, epidemiology and health services.

 

Disease/Disorder

 

Behavioral Health

 

Species

 

Human

 

Methods

 

Research design and statistics.

 

Key Collaborators

 

Alireza Amirsadri and Mark Greenwald

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

DPBN Profile View

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Eishi Asano, M.D., Ph.D.
Professor

Pediatrics; Neurology

Research Interest

 

The core aim of the research pursued in my laboratory is to generate functional brain atlases in four dimensions, incorporating ‘space’ as well as ‘time’, using unique intracranial electrophysiological signals in patients who undergo surgical resection of a seizure focus and/or tumor.

Disease/Disorder

 

Epilepsy and brain tumor.

Species

 

Human

Methods

 

EEG, Intracranial electrocorticography (ECoG), Cortico-cortical evoked potentials (CCEPs), Diffusion weighted tractography, 3D-surface rendered MRI, Neuropsychological tests, Eye tracking system.

Key Collaborators

 

Harry T. Chugani, MD, Csaba Juhasz, MD, PhD, Justin Jeong, PhD, Robert Rothermel, PhD, Sandeep Sood, MD, Noa Ofen, PhD, Otto Muzik, PhD.

Research Connect

 

Profile

Publications

 

PubMed Search (past 5 years).

Division/Laboratory

 

Department of Neurodiagnostics (EEG lab); Epilepsy surgery program

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Joyce Benjamins, Ph.D.
Professor and Associate Chair for Research

Neurology

Research Interest

 

Research interests include regulation of myelination, glial differentiation, and the roles of metabotropic glutamate receptors and the kynurenine pathway in mediating oligodendroglial injury. One current project investigates the effects of glutamate receptor agonists and antagonists on disease outcome in EAE, an animal model of multiple sclerosis. A collaboration with Dr. Lisak utilizes gene arrays to investigate the effects of cytokines on gene expression in CNS neurons and glia.

Disease/Disorder

 

Diseases affecting myelin, including multiple sclerosis, genetic disorders and neurodegenerative disorders. 

Species

 

Rats and mice.

Methods

 

Western blotting, PCR, gene array analysis and immunocytochemistry.

Key Collaborators

 

Robert Lisak and John Kamholz

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Neurology Profile View

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Bruce Berkowitz, Ph.D.
Professor

Anatomy & Cell Biology; Ophthalmology

Research Interest

 

Our goal is to prevent vision loss and blindness due to diabetic retinopathy and neurodegenerative disease. We develop and apply functional MRI methods to detect the effectiveness of a treatment earlier in the course of disease than is currently possible.

Disease/Disorder

 

Diabetic retinopathy, retinopathy of prematurity, age-related macular degeneration and retinitis pigmentosa

Species

 

Human, rats and mice.

Methods

 

Manganese-Enhanced MRI  (MEMRI).

Key Collaborators

 

Tim Kern (Case Western Reserve University), Paul Tofts (Brighton and Sussex Medical School, England)

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory

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George Borszcz, Ph.D.
Associate Professor

Psychology

Research Interest

 

Neurobiology of emotion and pain affect; fore-brain circuitry that governs individuals' innate emotional reaction to threatening/painful stimuli; evaluation of how plasticity within this forebrain circuit results in development of depression and anxiety.

Disease/Disorder

 

Neurobiology of emotion, particularly the emotional response to pain.

 

Species

 

Rats

Methods

 

Brain stimulation, electrophysiological recording, HPLC, histological staining and immunohistochemistry.

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Affective Neuroscience Laboratory

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Scott Bowen, Ph.D.
Associate Professor

Psychology

Research Interest

 

Research focuses on behavioral pharmacology, behavioral toxicology, and neurobehavioral teratology, also to understand why volatile organic solvents, such as toluene and nitrous oxide, are abused.

Disease/Disorder

 

Behavioral pharmacology and toxicology of commonly abused drugs.

Species

 

Rats and mice.

Methods

 

Rodent models/tests for anxiety or depression behaviors, activity, memory, operant methods of reinforcement, and developmental milestones.

 

Key Collaborators

 

John Hannigan, Shane Perrine, Alana Conti, Susanne Brummelte, George Borszcz, Matthew Galloway.

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Behavioral Pharmacology and Toxicology Laboratory

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Susanne Brummelte, Ph.D.
Assistant Professor

Psychology

Research Interest

 

Developmental Neuroscience, Neuroendocrinology, Behavioral Neuroscience.
My current research focuses on the effects of early adverse life experience on brain development and the subsequent behavioral and neuroanatomical changes in both, males and females. I am particularly interested in the consequences of exposure to depression, antidepression medication, stress or glucocorticoids and pain during the prenatal or postnatal period.

Disease/Disorder

 

(maternal) depression, stress, pain

 

Species

 

Rats 

Methods

 

Behavioral testing, immunohistochemistry, western blotting, ELISAs etc.

 

Key Collaborators

 

Shane Perrine, Scott Bowen, George Borszcz, Carolyn Herrington

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Developmental Psychobiology Lab

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Paul R. Burghardt, Ph.D.
Assistant Professor

Nutrition & Food Science

Research Interest

 

To understand how metabolism reciprocally intermingles with brain function to influence behavior.

 

Disease/Disorder

 

Obesity, prediabetes, depression.

 

Species

 

Human and rat.

Methods

 

PET, MRI, in situ hybridization, immunohistochemistry, ELISA, RIA.

 

Key Collaborators

 

Jeffrey Stanley

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Creme Laboratory

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Leon Carlock, Ph.D.
Associate Professor

Center for Molecular Medicine and Genetics; Anatomy & Cell Biology

Research Interest

 

Cell Based Assays for cell stress and death, Entrepreneurship, Technology development and Translational Research.

Disease/Disorder

 

Oncology

Species

 

Human cells.

Methods

 

Novel technology based upon ribosomal translational activity in normal and stressed/dying cells

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Center for Molecular Medicine and Genetics

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Alana C. Conti, Ph.D.
Assistant Professor

Neurological Surgery; Pediatric Neurosurgery

Research Interest

 

Experiments designed to examine ethanol action at the cellular level and to define the signaling pathways that mediate the synaptic response to ethanol in the adult and juvenile brain. Additional studies focus on behavioral outcome following ethanol exposure. Of particular interest are the proteins, adenylyl cyclase 1 and 8, which promote neuronal survival in the neonatal brain following ethanol treatment in studies related to Fetal Alcohol Syndrome. Future projects will focus on development of a novel in vitro model of Fetal Alcohol Syndrome and defining the cellular mechanisms that regulate ethanol sensitivity following traumatic brain injury using both adult and juvenile mouse models.

Disease/Disorder

 

Traumatic brain injury, fetal alcohol spectrum disorder and alcohol sensitivity.

Species

 

Mice

Methods

 

Molecular Biology, Immunohistochemistry, Primary Neuronal Cultures, Behavioral Animal Models.

Key Collaborators

 

Don Kuhn, Scott Bowen, Tiffany mathews, Shane Perrine, John Hannigan

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Conti Lab

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Jessica S. Damoiseaux, Ph.D.
Assistant Professor

Psychology; Institute of Gerontology

Research Interest

 

Changes in functional and structural brain connectivity in normal and abnormal aging, with a specific focus on the early detection of Alzheimer’s disease.

Disease/Disorder

 

Healthy aging and Alzheimer’s disease.

Species

 

Human

Methods

 

functional MRI; diffusion MRI; neuropsychological assessment.

Key Collaborators

 

Serge Rombouts and Jeroen van der Grond, Leiden Institute for Brain and Cognition, the Netherlands.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Connect Lab

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Donald J. DeGracia, Ph.D.
Associate Professor

Physiology

Research Interest

 

We study the mechanisms of cell death following brain ischemia and reperfusion, focusing on the causes and consequences of reperfusion-induced inhibition of protein synthesis, or translation arrest.  This translation arrest appears to be part of the post-ischemic neuronal stress response.  We have evaluated classical ribosome biochemistry, intracellular stress responses and most recently began investigating mRNA regulatory mechanisms, including stress granules and HuR granules.  The lab is currently funded by the National Institute of Neurological Disorders and Stroke at the NIH.

Disease/Disorder

 

Brain ischemia and reperfusion injury: stroke, cardiac arrest and resuscitation brain damage.

Species

 

Rodents

Methods

 

Molecular biology.

Key Collaborators

 

Jose Rafols, Ph.D.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Degracia Laboratory

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Vaibhav A. Diwadkar, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences; Psychology

Research Interest

 

Using imaging to study the functional organization of cortico-striatal and cortico-limbic networks in normal development and to understand dysfunction in these circuits in vulnerable and disordered adolescent populations.

Disease/Disorder

 

Schizophrenia and mood disorders.

Species

 

Human

Methods

 

fMRI and neuropsychology tests.

Key Collaborators

 

Jeffrey Stanley, Nash Boutros, Bob Freedman, David Rosenberg, Otto Muzik, Harry Chugani, Diane Chugani, Joseph Jacobson, Sandra Jacobson

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Brain Imaging Research Division

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Alan Dombkowski, Ph.D.
Assistant Professor

Pediatrics

Research Interest

 

Under two federally funded grants we are studying molecular contributors to the epileptogenic potential of cortical tubers in tuberous sclerosis complex (TSC). We use genomic and bioinformatics technologies to characterize gene and protein expression patterns, microRNAs, mutations, and epigenetic modifications in human brain tissue resected for the treatment of intractable epilepsy. The outcomes of this research are expected to expand our understanding of epilepsy in TSC, identify novel therapeutic targets, and improve diagnostic imaging methods.

Disease/Disorder

 

Tuberous sclerosis complex, Epilepsy.

Species

 

Human (brain tissue, cell culture)

Methods

 

Next-generation sequencing, Microarrays, RT-PCR, Proteomics.

Key Collaborators

 

Harry Chugani, Diane Chugani, Eishi Asano, Paul Stemmer.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory of Functional Genomics and Bioinformatics

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Paula Dore-Duffy, Ph.D.
Professor

Neurology

Research Interest

 

The role of the microvascular pericyte in vascular function and CNS vascular diseases.  The pericyte is an integral member of the blood brain barrier and neurovascular unit.  As such it functions as a regulator cell and is involved in regulation of focal capillary blood flow, angiogenesis, inflammation and is now known to be a source of adult stem cells. Ongoing studies include investigation of pericytes in stem cell therapeutic paradigms in EAE and Traumatic brain injury.

Disease/Disorder

 

Multiple sclerosis, traumatic brain injury and stroke

 

Species

 

Rats and mice.

Methods

 

Immune based techniques, cell culture, molecular biology, protein chemistry, FACs analysis, imaging and translational research.

Key Collaborators

 

Alexander Gow, Jose Rafols, Christian Kreipke, William Brusilow and Richard Needleman, and outside the University Joseph Lamanna and Robert Miller at Case Western Reserve School of Medicine in Cleveland and Richard Milner at Scripps Research Institute and Gregory del Zoppo at the University of Washington in Seattle.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Neurology Profile View

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Nora Fritz, PhD, PT, DPT, NCS
Assistant Professor

Pharmacy & Health Science (Physical Therapy); Neurology

Research Interest

 

Our lab examines the influence of cognition on mobility and explores exercise interventions to improve function in individuals with neurologic conditions. We are particularly interested in linking clinically observable function to structural imaging and predicting the outcomes of exercise interventions using neuroimaging.

Disease/Disorder

 

Neurodegenerative diseases including Multiple Sclerosis and Huntington’s disease.

Species

 

Human

Methods

 

MRI, 3D motion capture, quantitative strength and sensory testing, neuropsychological testing.

Key Collaborators

 

Kathy Zackowski (Johns Hopkins University); Anne Kloos and Deb Kegelmeyer (The Ohio State University); Lori Quinn (Teacher’s College, Columbia University).

Research Connect

 

Profile

Publications

 

PubMed Search (past 5 years).

Division/Laboratory

 

Neuroimaging and Neurorehabilitation Laboratory (NNL)

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Alexander Gow, Ph.D.
Professor

Center for Molecular Medicine and Genetics; Pediatrics; Neurology

Charles H. Gershenson Distinguished Fellow

Associate Director, Center for Molecular Medicine and Genetics

Research Interest

 

White matter disease and relevance to cognitive deficits.

Disease/Disorder

 

Depression, multiple sclerosis, Pelizaeus-Merzbacher, Auditory Processing Disorder

 

 

Species

 

Mouse and Human

Methods

 

Knockout and transgenic mice, confocal and electron microscopy, psychoacoustics, behavior, MRI ad MRS, biochemistry, microarrays, computational modeling, drug testing to ameliorate neurodegeneration

 

Key Collaborators

 

Robert Skoff, Anatomy and Cell Biology (WSU); Zhengqing Hu, Otolaryngology (WSU); Paula Dore-Duffy, Neurology (WSU); Jeff Stanley, Psychiatry (WSU); Shane Perrine, Psychiatry (WSU); Matthew Galloway, Psychiatry (WSU); Greg Auner, Biomedical Engineering (WSU)

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Center for Molecular Medicine and Genetics

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James Granneman, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences; Pathology

Research Interest

 

Adipose tissue remodeling, molecular mechanisms of lipolysis in fat and muscle,  drug target discovery.

Disease/Disorder

 

Diabetes and obesity.

Species

 

Mice.

Methods

 

Confocal microscopy, live cell protein-protein interaction assays, molecular biology, cell biology and high throughput compound screening

Key Collaborators

 

HP Moore, Ryan Thummel, Mark Cheng, Guangzhao Mao

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Center for Integrative Metabolic and Endocrine Research (CIMER)

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Mark Greenwald, Ph.D.
Professor and Associate Chair-Research

Psychiatry & Behavioral Neurosciences; Psychology

Research Interest

 

Pharmacological, environmental and individual difference determinants of drug-seeking/use behavior (primary endpoint) and neural processes (measured with in vivo imaging methods) related to these behaviors.

Disease/Disorder

 

Opioid, cocaine, marijuana, nicotine, and alcohol use disorders.

Species

 

Human

Methods

 

PET (opioid and dopamine), 1H spectroscopy, fMRI and EEG.

 

Key Collaborators

 

Leslie Lundahl, David Ledgerwood and Cynthia Arfken (substance use disorders, HIV/AIDS); Jeffrey Stanley (1H spectroscopy); Vaibhav Diwadkar (fMRI, learning/memory); Sylvie Naar-King and Paul Burghardt (stress, physical activity and obesity); Terrance Albrecht, Ann Schwartz and Jennifer Beebe-Dimmer (KCI: chemotherapy-induced peripheral neuropathy); Timothy Roehrs (Henry Ford: EEG, sleep, pain); Margit Burmeister (Univ. of Michigan: pharmacogenetics).

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Substance Abuse Research Division

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E. Mark Haacke, Ph.D.
Professor

Biomedical Engineering; Radiology

Research Interest

 

We are interesting in a wide variety of neuroimaging applications related to neurovascular diseases from Multiple Sclerosis to dementia.

Disease/Disorder

 

Stroke, trauma, cancer, multiple sclerosis and aging.

 

Species

 

Human, rats and mice.

Methods

 

MRI

 

Key Collaborators

 

Jiani Hu, Norman Cheng, Zhifeng Kou, Albert King, Randy Benson and James Garbern

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

MR Research Facility

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John Hannigan, Ph.D.
Professor

Obstetrics and Gynecology; Psychology

Research Interest

 

Neurobehavioral effects of prenatal drug and alcohol exposure.

Disease/Disorder

 

Fetal alcohol spectrum disorder. 

Species

 

Rats, mice and human.

Methods

 

MRI, MRS and fMRI. 

Key Collaborators

 

Lisa Chiodo, Jeffrey Stanley, Viabhav Diwadkar and Scott Moffat

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

MPSI Profile View

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Jiani Hu, Ph.D.
Associate Professor

Radiology

Research Interest

 

Exploring in vivo MR properties of lesions for diagnosis, prognosis and treatment follow-up using the state-of-art in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques.

Disease/Disorder

 

Neurological disorders and cancers.

Species

 

Human and small animals.

Methods

 

MRI and MRS.

 

Key Collaborators

 

Mark Haacke

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

MR Research Facility

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Joseph L. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Effects of prenatal exposure to alcohol and environmental contaminants (PCBs, mercury, lead) on infant and child development; research methods; study design.

Disease/Disorder

 

Fetal alcohol syndrome, fetal alcohol spectrum disorder, ADHD and alcohol abuse and dependence.

Species

 

Human.

Methods

 

Neuropsychological assessment, structural MRI, functional MRI and diffusion tensor imaging.

 

Key Collaborators

 

Sandra W. Jacobson (all studies), Christopher Molteno and Ernesta Meintjes (Cape Town neuroimaging and neurobehavioral studies), Gina Muckle (Inuit studies).

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Child Development

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Sandra W. Jacobson, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Studying the effects of prenatal exposure to alcohol, cocaine, smoking and environmental contaminants (PCBs, mercury, lead) on infant and child development, using state-of-the-art neurobehavioral and neuroimaging outcome measures.

Disease/Disorder

 

Fetal alcohol syndrome (FAS), fetal alcohol spectrum disorder (FASD), attention deficit hyperactivity disorder (ADHD), alcohol abuse and dependence in pregnant women and adolescents.

Species

 

Human

Methods

 

Eyeblink conditioning, fMRI, sMRI, DTI, infant and child neuropsychological assessment (standardized and nonstandardized tests) and  alcohol and drug ascertainment and dependence.

Key Collaborators

 

Joseph L. Jacobson (all studies), Mark Stanton (EBC), Christopher Molteno and Ernesta Meintjes (Cape Town fMRI and neurobehavioral studies), Gina Muckle (Inuit studies), Cynthia Bearer (meconium), Tim Oberlander and Joanne Weinberg (cortisol and pain reactivity), Charles Nelson (ERP).

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Child Development

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Arash Javanbakht, M.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Neurobiology of cognitive (e.g. personal interpretation of the event), cultural, physical, and temporal context in development of negative effects of trauma and PTSD. I am also interested in use of virtual reality and other technological advances in combination with psychotherapy and medications in treatment of GAD, phobias, and PTSD.

 

Disease/Disorder

 

GAD, Phobias, PTSD, Depression

 

Species

 

Human

Methods

 

Skin Conductance, fMRI, Genetics, Cortisol.

 

Key Collaborators

 

Vaibhav Diwadkar, David Rosenberg, Alireza Amirsadri, Cynthia Arfken, Shane Perrine, Israel Liberzon (UofM).

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Stress, Trauma, and Anxiety Research and Clinical Program

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juhasz

 

Csaba Juhasz, M.D., Ph.D.
Professor

Pediatrics; Neurology

Research Interest

 

Functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders with a particular interest in the pathophysiology and progression of Sturge-Weber Syndrome.

Disease/Disorder

 

Epilepsy, brain tumors,  Sturge-Weber Syndrome and developmental brain disorders.

Species

 

Human.

Methods

 

PET and MR imaging, EEG.

 

Key Collaborators

 

Sandeep Mittal, Otto Muzik, Jiani Hu, Eishi Asano, Jeong-Won Jeong, Michael Behen, Geoffrey Barger.

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

PET Center & Translational Imaging Laboratory

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Zhifeng Kou, Ph.D.
Associate Professor

Biomedical Engineering & Radiology

Research Interest

 

Advanced magnetic resonance imaging (MRI) of traumatic brain injury (TBI). We use advanced MRI to improve the detection and outcome prediction of brain trauma and further guide the clinical management and potential treatment of TBI.

Disease/Disorder

 

Traumatic brain injury

Species

 

Human and rodent animal models

Methods

 

Advanced MRI, including susceptibility weighted imaging and mapping, diffusion and perfusion imaging, MR spectroscopy imaging and functional imaging.

Key Collaborators

 

Robert Welch, M.D., John Woodard, Ph.D., Scott Millis, Ph.D., Randall Benson, M.D., John Cavanough, M.D., Robin Hanks, Ph.D.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Laboratory

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Donald M. Kuhn, Ph.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

We are interested in the role of non-neuronal cells in contributing to brain damage caused by drugs, disease and injury. We are also interested in the physiological and neurochemical roles played serotonin as determined through studies with a knockout mouse lacking brain serotonin (i.e., TPH2 knockout).

 

Disease/Disorder

 

Traumatic brain injury, parkinson’s disease, depression and OCD.

 

Species

 

Mice, brain tissue and bacteria.

Methods

 

Neurochemistry, biochemistry, pharmacology, molecular biology, transgenic and knockout mouse models of CNS diseases.

 

Key Collaborators

 

Mariana Angoa-Perez, Michael Kane, David M. Thomas, Christian W. Kreipke, Alana Conti, Matthew Galloway, Shane Perrine.

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Molecular Neurobiology

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David Ledgerwood, Ph.D.
Associate Professor

Psychiatry and Behavioral Neurosciences

Research Interest

 

Substance abuse treatment; Pathological gambling (problem gambling, compulsive gambling); Contingency management.

 

Disease/Disorder

 

Gambling disorder, nicotine dependence and substance use disorder. 

 

Species

 

Human

Methods

 

Clinical Trials

 

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Problem Gambling

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Leslie Lundahl, Ph.D.
Assistant Professor

Psychiatry and Behavioral Neurosciences

Research Interest

 

Human behavioral pharmacology of drugs of abuse; Medications development for treatment of substance use disorders; Cannabis; Co-morbid psychiatric and substance use disorders.

 

Disease/Disorder

 

 

 

Species

 

 

Methods

 

 

 

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

DPBN Profile View

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William Lyman, M.D.
Professor

Pediatrics; Psychiatry & Behavioral Neurosciences

Research Interest

 

Stem cells: the good, the bad and the ugly. Good stem cells for nervous system. The bad stem cells in cancer. The ugly stem cells in kidney disease because of the dispute about whether they even exist.

Disease/Disorder

 

Fetal alcohol spectrum disorder, neuroblastoma, cerebral palsy, nephrotic syndrome and tubular necrosis.

 

Species

 

Fetal human brain, blood and kidney tissues.

Methods

 

Cell, tissue culture and molecular biology and functional genomics.

 

Key Collaborators

 

S. Vangipuram, J. Wang, N. Choutai, G. Kapur, T. Mattoo, R. Novak, A. Dombkowski.

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Children’s Research Center of Michigan

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Otto Muzik, Ph.D.
Associate Professor

Pediatrics; Radiology; Neurology

Research Interest

 

PET imaging and Pediatric imaging.

Disease/Disorder

 

Epilepsy, Brown Adipose Tissue (BAT).

 

Species

 

Human.

Methods

 

PET and fMRI.

Key Collaborators

 

Vaibhav Diwadkar

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Positron Emission Tomography (PET) Center

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 ofen

Noa Ofen, Ph.D.
Assistant Professor

Institute of Gerontology; Pediatrics

Research Interest

 

The typical and atypical development of memory systems in the human brain. Functional and structural brain development. Relationship between variation in cognitive and brain development and genetic polymorphism.

Disease/Disorder

 

Developmental disorders, prematurity, schizophrenia.

Species

 

Human

Methods

 

MRI, fMRI, DTI, cognitive assessment, genetics.

Key Collaborators

 

Viabhav Diwadkar, Jeffrey Stanley, Naftali Raz, Joe Jacobson, Sandra Jacobson, Sarah Raz, Moriah Thomason.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Ofen Lab

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Shane A. Perrine, Ph.D.
Assistant Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Our laboratory focuses on the neuropsychopharmacology of drug addiction and co-occurring psychiatric conditions, namely depression and anxiety. The goal of my research is to elucidate the mechanisms by which drugs, particularly psychostimulants such as cocaine, methamphetamine, and methylenedioxymethamphetamine (ecstasy), affect neurochemistry and behavior. Using animal models, we seek to identify and understand the plasticity of the human brain in response to acute and repeated drug exposure, as well as, stressors and cues that lead to anxiety, depression and relapse to drug seeking. We are currently pursuing two major research studies: 1) Determine the neurochemical underpinnings that are disrupted by psychostimulants and lead to anxiety, depression and maladaptive reward behaviors; 2) Understand the neurobiological basis that underlies comorbidity of PTSD and drug abuse.

Disease/Disorder

 

Drug abuse and dependence, anxiety and depression.

Species

 

Rat

Methods

 

Rodent models/tests for reward, anxiety, and depression related behaviors, western blotting, ELISA, HPLC, and proton-magnetic resonance spectroscopy.

Key Collaborators

 

Matthew Galloway, Manuel Tancer, Mark Greenwald, Scott Bowen, Jeffrey Stanley, David Thomas, Donald Kuhn, Alana Conti, Pamela VandeVord, Michael Church, Bill Fantegrossi (U Arkansas), Leonard Howell (Emory U), Israel Liberzon (U Michigan), Mark Simmons (NEOUCOMP) and Ellen Unterwald (Temple U).

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years)

Division/Laboratory

 

Neuropharmacology of Addiction

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Christine A. Rabinak, Ph.D.
Assistant Professor

Pharmacy Practice

Research Interest

 

Behavioral and neurobiological mechanisms of fear learning and memory; cannabinoid system and emotional processing; threat perception and regulations of affect; biomarkers of development and maintenance of anxiety disorders.

Disease/Disorder

 

Anxiety disorders, Trauma

Species

 

Human

Methods

 

fMRI, EEG, ERP, psychopharmacology, behavior and virtual reality.

Key Collaborators

 

Mark Greenwald (WSU), Jeff Stanley (WSU), K. Luan Phan (University of Illinois at Chicago), Mohammed Milad (MGH & Harvard), Greg H. Proudfit (SUNY Stony Brook), Moriah Thomason (WSU).

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Translational Neuropsychopharmacology Laboratory

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Naftali Raz, Ph.D.
Professor

Institute of Gerontology; Psychology

Research Interest

 

Differential brain aging, its modification by genetic and pathophysiological factors, and its cognitive consequences.

Disease/Disorder

 

Cognitive aging

 

Species

 

Human

Methods

 

MRI and cognitive psychology.

Key Collaborators

 

E. Mark Haacke, Ulman Lindenberger (Max Planck Institute for Human Development, Berlin),  Paolo Ghisletta (University of Geneva, Switzerland), Jeffrey Stanley.

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Cognitive Neuroscience of Aging

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David Rosenberg, M.D.
Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

Our lab is focused on uncovering the neurobiology of pediatric mental illness and translating those findings into advances in diagnostics and treatment.

Disease/Disorder

 

Obsessive Compulsive Disorder, major depression, and bipolar disorder

Species

 

Human (pediatric)

Methods

 

MRI, MRS, fMRI, genetics and cortisol.

Key Collaborators

 

Vaibhav Diwadkar, Jeffrey A Stanley, Paul Arnold & Jim Kennedy (University of Toronto), Greg Hanna (University of Michigan)

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Child and Adolescent Research Services

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John SantaLucia, Ph.D.
Professor

Chemistry

Research Interest

 

NMR structure, Determination of RNA, Development of antibiotics.

Disease/Disorder

 

Bacterial infections. Combating drug resistance. 

Species

 

E. Coli

Methods

 

NMR spectroscopy, x-ray crystallography, electron microscopy, FRET, and gel electrophoresis.

Key Collaborators

 

Philip R. Cunningham (WSU), Christine Chow (WSU).

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

SantaLucia Laboratory

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Navid Seraji-Bozorgzad, M.D.
Assistant Professor

Neurology

Research Interest

 

Biomarkers of brain injury and repair, as it applies to various degenerative disorders, including Alzheimers disease.

 

Disease/Disorder

 

Neurological Diseases.

 

Species

 

Human

Methods

 

MRI, PET, 3D optical coherence tomography

 

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Neurology Profile

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Jeffrey A. Stanley, Ph.D.
Associate Professor

Psychiatry & Behavioral Neurosciences

Research Interest

 

To gain a greater understanding of the neural basis of neurodevelopment, aging and diffefferent disorder from the perspective of morphology, function and biochemistry using different MR methodologies.

Disease/Disorder

 

schizophrenia, aging, ADHD, OCD, anxiety and mood disorders

 

Species

 

Human

Methods

 

MRS, fMRS, fMRI, myelin imaging, structural MRI

 

Key Collaborators

 

Vaibhav Diwadkar, Naftali Raz, Paul Burghardt, Mark Greenwald, Konasale M. Prasad (U. of Pittsburgh), Jair Soares (U. of Texas at Houston), Paolo Brambilla (U. of Milan)

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Brain Imaging Research Division

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Manuel Tancer, M.D.
Professor

Psychiatry & Behavioral Neurosciences; Pharmacology

Research Interest

 

Effects of MDMA (Ecstasy) measured with fMRI and MRS.

Disease/Disorder

 

 

 

Species

 

Human

Methods

 

 

 

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

DPBN Profile View

 

 

top

 

 


 

 

John Woodard, Ph.D.
Professor

Psychology

Research Interest

 

Neuropsychological and neuroimaging studies of memory in aging and dementia; Cognitive and health-related risk factors for late life anxiety; Detection and tracking of sport related concussion; Statistical and methodological issues in neuropsychological test construction and assessment.

Disease/Disorder

 

 

 

Species

 

 

Methods

 

 

 

Key Collaborators

 

 

 

Research Connect

 

Profile

 

Publications

 

PubMed Search (past 5 years).

 

Division/Laboratory

 

Psychology

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